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Cardiovascular Risk in Patients with Primary Hyperparathyroidism
Symeon Tournis1, Konstantinos Makris2, Etienne Cavalier3
1Laboratory for Research of the Musculoskeletal System "Th. Garofalidis", National and Kapodistrian University of Athens, KAT Hospital, Athens, Greece.
Current Pharmaceutical Design
|November 6, 2020
Summary
Primary hyperparathyroidism (PHPT) can affect the cardiovascular system. Surgery
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Nephrology
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder causing hypercalcemia.
- Parathyroid hormone (PTH) influences cardiovascular function.
- PHPT is associated with cardiovascular risk factors and events, particularly in severe cases.
Purpose of the Study:
- To review the evidence linking PHPT and cardiovascular disease (CVD).
- To evaluate the impact of surgical and pharmacological treatments on CVD in PHPT patients.
Main Methods:
- Review of experimental and observational studies.
- Analysis of existing literature on PHPT and cardiovascular outcomes.
Main Results:
- PHPT is linked to hypertension, diabetes, lipid abnormalities, and left ventricular hypertrophy.
- The effect of surgery on cardiovascular abnormalities and events in PHPT is inconsistent, especially in mild cases.
- Cardiovascular disease is not currently an indication for PHPT surgery.
Conclusions:
- CVD manifestations in PHPT require careful consideration.
- Surgical intervention for PHPT does not consistently improve cardiovascular outcomes.
- Further research is needed to clarify the role of treatment in managing CVD in PHPT.
Keywords:
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