Related Experiment Video

Updated: Dec 1, 2025

Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
09:53

Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation

Published on: January 10, 2025

695

Cardioprotective Effects of Natural Products via the Nrf2 Signaling Pathway

Rasool Tavakoli1, Jamshid Tabeshpour2, Javad Asili1

  • 1Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Vascular Pharmacology
|November 6, 2020
PubMed

Insights

Natural products can activate Nuclear factor erythroid-2-related factor 2 (Nrf2) to enhance cardiomyocyte antioxidant potential. This review explores natural products for potential therapeutic benefits against heart disease.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Pharmacology

Background:

  • The heart's limited regeneration makes it susceptible to injury from toxins, ischemia/reperfusion, and other conditions.
  • Nuclear factor erythroid-2-related factor 2 (Nrf2) is crucial for protecting heart cells (cardiomyocytes) from oxidative stress.
  • Nrf2 regulates antioxidant and detoxification genes via the antioxidant response element.

Purpose of the Study:

  • To review the cardioprotective effects of natural products.
  • To explore the therapeutic potential of these natural products in heart conditions.

Main Methods:

  • Literature review of studies on natural products and Nrf2 activation.
  • Analysis of mechanisms underlying Nrf2-mediated cardioprotection.
  • Evaluation of therapeutic applications.

Main Results:

  • Various natural products have demonstrated the ability to activate Nrf2.
  • Nrf2 activation by natural products boosts the antioxidant capacity of cardiomyocytes.
  • These compounds show promise in mitigating heart damage.

Conclusions:

  • Natural products represent a promising avenue for developing novel cardioprotective therapies.
  • Targeting the Nrf2 pathway with natural compounds could offer a strategy to combat heart disease.
Keywords:
Anti-apoptoticAntioxidantCardioprotectiveCardiovascular diseases.Natural productsNuclear factor erythroid-2-related factor 2

More Related Videos

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

6.8K
Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.4K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.0K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
700
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.8K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.1K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
243