Related Experiment Video
Updated: Dec 1, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Vitor F Ferreira1, Alcione S de Carvalho2, Patricia G Ferreira1
1Universidade Federal Fluminense, Faculdade de Farmacia, Departamento de Tecnologia Farmaceutica, Niteroi, 24241-000, RJ, Brazil.
Background:
Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.
Objective:
The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.
Methods:
We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.
Results:
In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.
Conclusion:
A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.
More Related Videos
05:59Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
Published on: September 27, 2024
10:29Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Related Concept Videos
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Principles of Drug Action
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
The Electron Transport Chain
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...