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[The changes of left ventricular longitudinal systolic function depending on hypertension and its control: analysis

V P Guseva1, A N Ryabikov1, E V Voronina1

  • 1Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences; Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia.

Kardiologiia
|November 6, 2020
PubMed

Insights

Arterial hypertension (AH) significantly impairs left ventricular (LV) systolic function, as measured by global longitudinal strain (GLS) and global strain rate (GSR). Ineffective blood pressure control in AH patients leads to the most pronounced decline in LV systolic function.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Arterial hypertension (AH) is a prevalent condition affecting cardiovascular health.
  • Left ventricular (LV) systolic function is crucial for maintaining cardiac output.
  • Assessing LV systolic function using global longitudinal strain (GLS) and global strain rate (GSR) provides valuable insights into myocardial performance.

Purpose of the Study:

  • To evaluate changes in LV systolic function, specifically GLS and GSR, in patients with AH.
  • To investigate the impact of blood pressure (BP) control effectiveness on LV systolic function in an older Russian population.
  • To determine the association between AH, BP control, and LV myocardial strain parameters.

Main Methods:

  • Cross-sectional, population-based cohort study (HAPIEE, Novosibirsk) including 1004 individuals aged 55-84 years.
  • Echocardiography was used to measure LV myocardial GLS and GSR.
  • Statistical analysis involved multivariate logistic regression models to assess associations.

Main Results:

  • AH prevalence was high at 78.4% in the study sample.
  • Individuals with AH exhibited significantly lower absolute values of GLS and GSR compared to normotensive individuals, irrespective of age, gender, or body weight index.
  • The lowest GLS and GSR values were observed in the "ineffectively treated" or untreated AH groups, indicating a decline in LV systolic function with inadequate BP control.
  • AH increased the risk of LV GLS decrease by 1.6 times and LV GSR decrease by 2 times.

Conclusions:

  • LV GLS and GSR are independently associated with arterial hypertension in this Russian population.
  • Ineffective control of AH is linked to a significant decline in LV systolic function, as evidenced by reduced GLS and GSR.
  • These findings highlight the importance of effective BP management for preserving LV systolic function in hypertensive individuals.

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