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Fluorescent imaging of cytoplasmic nucleolin in live cells by a functionalized-engineered aptamer
Junfa Yin1, Shaokun Chen, Yuanyuan Song
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China. hlwang@rcees.ac.cn.
Chemical Communications (Cambridge, England)
|November 6, 2020
Abstract:
Monitoring of over-expressed nucleolin in the cytoplasm facilitates early cancer diagnosis. Herein, we present a novel biosensing nanoscaffold based on anti-nucleolin aptamers and polymer-grafted graphene oxides for the fluorescent imaging of nucleolin in the cell cytoplasm, which can distinguish cancer cells from normal cells.
