DDBJ update: streamlining submission and access of human data.

Area of Science:

• Bioinformatics
• Genomics
• Data Archiving

Background:

• The Bioinformation and DDBJ Center (DDBJ Center) is crucial for managing and disseminating biological data.
• It collaborates internationally (NCBI, EBI) within the International Nucleotide Sequence Database Collaboration (INSDC).
• The Japanese Genotype-phenotype Archive (JGA) provides controlled access to human genetic data.

Purpose of the Study:

• To report updates and enhancements to DDBJ Center services.
• To detail system improvements for the National Bioscience Database Center (NBDC) and JGA.
• To highlight the integration of NBDC and JGA systems for streamlined data management.

Main Methods:

• Integration of NBDC and JGA systems via a unified login platform with group structure.
• Continued collection and dissemination of nucleotide sequences, raw sequencing data, and alignment information.
• Provision of computational resources, including the NIG supercomputer, for large-scale genomic data analysis.

Main Results:

• A unified login platform for NBDC and JGA was implemented in September 2020.
• Enhanced data management and accessibility for human genotype-phenotype data.
• Improved infrastructure for analyzing large-scale genomic data.

Conclusions:

• The DDBJ Center has successfully enhanced its data archiving and dissemination services.
• System integration has streamlined access to sensitive human genetic data.
• These updates support advanced life science research through improved data accessibility and computational resources.