Pancreas ultrasound two-dimensional shear wave elastography in healthy children
Lisa Qiu1, Andrew T Trout2,3,4, Paula S Bennett1
1Department of Radiology, Cincinnati Children's Hospital Medical Center, MLC 5031, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
Insights
Pancreas shear wave speed, measured by ultrasound shear wave elastography (SWE), may serve as a biomarker for pancreatic health in children. This study established normal reference values in a healthy pediatric cohort.
Area of Science:
- Pediatric imaging
- Biomarker discovery
- Medical diagnostics
Background:
- Pancreas shear wave speed (SWS) shows potential as a biomarker for pancreatic diseases in pediatric populations.
- Establishing normal SWS values in healthy children is crucial for accurate diagnosis and monitoring.
Purpose of the Study:
- To measure pancreas SWS using two-dimensional (2-D) ultrasound shear wave elastography (SWE).
- To establish reference values for pancreas SWS in a balanced cohort of presumed healthy children.
Main Methods:
- Prospective study of 120 children (<18 years) without known pancreatic disease.
- Ultrasound 2-D SWE of the pancreas was performed, obtaining five measurements per participant.
- Statistical analyses included Mann-Whitney U, Kruskal-Wallis, Spearman's correlation, and multivariable regression.
Main Results:
- Median pancreas SWS was 1.31 m/s (IQR: 1.21-1.40) in 120 children (median age 5.0 years).
- Factors positively associated with pancreas SWS included female sex, nil per os duration, measurement depth, and liver SWS.
- Reference values for normal pancreas SWS in children were established.
Conclusions:
- This study provides reference pancreas SWS values for a large, balanced cohort of healthy children.
- Ultrasound SWE is a viable method for assessing pancreas stiffness in pediatric patients.
- Pancreas SWS may serve as a valuable, non-invasive biomarker for pediatric pancreatic health.
Background:
Pancreas shear wave speed might be a biomarker of pancreatic disease in children.
Objective:
This study aimed to measure pancreas shear wave speed by two-dimensional (2-D) ultrasound shear wave elastography (SWE) in a balanced cohort of presumed healthy children.
Materials And Methods:
This was a prospective study of 120 children (<18 years of age) without a known history of pancreatic disease, who underwent ultrasound 2-D SWE of the pancreas. Five shear wave speed measurements in the pancreas body and/or tail were obtained for each participant using a Canon Aplio i800 system, i8CX1 transducer. The Mann-Whitney U test or Kruskal-Wallis test were used to compare continuous distributions. Spearman's correlation was used to assess univariate relationships between continuous variables. Multivariable regression with stepwise selection was used to evaluate independent predictors of pancreas shear wave speed.
Results:
The median age for the study population was 5.0 years (range: 7 days to 17.8 years) and 61 (50.8%) of the participants were female. The median depth of shear wave speed measurement was 4.7 cm (interquartile range [IQR]: 4.2-5.3). The median pancreas shear wave speed was 1.31 m/s (IQR: 1.21-1.40). On multivariable analysis, female biological sex (P=0.051), the number of hours nil per os (P=0.097), the median depth of measurement (P=0.001) and the median liver shear wave speed (P=0.020) were positively associated with pancreas shear wave speed.
Conclusion:
We report pancreas shear wave speed in a large, balanced cohort of children without a known history of pancreatic disease, providing reference values for normal.
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