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Reduced JKAP correlates with advanced disease features, inflammation, as well as increased exacerbation risk and
Hong Han1, Jianli Lu1, Cuirong Chen2
1Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xiangdu District, Xingtai, 054001, China.
Insights
JNK pathway-associated phosphatase (JKAP) levels are lower in children with asthma exacerbations and correlate with inflammation and disease severity. JKAP shows potential as a biomarker for asthma susceptibility and risk in pediatric patients.
Area of Science:
- Pediatric Pulmonology
- Immunology
- Biomarker Discovery
Background:
- Asthma is a chronic respiratory disease affecting children worldwide.
- Identifying reliable biomarkers for asthma management is crucial.
- JNK pathway-associated phosphatase (JKAP) role in pediatric asthma is under investigation.
Purpose of the Study:
- To investigate the correlation of JKAP with clinical features in asthmatic children.
- To assess JKAP's association with inflammation, exacerbation risk, and severity.
- To evaluate JKAP as a potential biomarker for pediatric asthma.
Main Methods:
- A case-control study involving 90 asthmatic exacerbation children, 90 asthmatic remission children, and 90 healthy controls.
- Analysis of venous blood samples for JKAP and inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17) using ELISA.
- Assessment of clinical features including pulmonary function (FEV1/FVC, FEV1 %predicted) and IgE levels.
Main Results:
- JKAP levels were significantly lower in asthmatic exacerbation children compared to remission and healthy groups.
- JKAP demonstrated good diagnostic ability to distinguish between the three groups (AUC: 0.926).
- JKAP negatively correlated with inflammatory markers (eosinophils, IgE, TNF-α, IL-1β, IL-6, IL-17) and positively with pulmonary function in exacerbation/remission groups.
Conclusions:
- JKAP is a potential biomarker for assessing asthma susceptibility and inflammation in children.
- JKAP levels correlate with asthma exacerbation risk and severity.
- JKAP may aid in the clinical management and risk stratification of pediatric asthma.
Background:
This study aimed to investigate the correlation of JNK pathway-associated phosphatase (JKAP) with clinical features, inflammation, exacerbation risk, and severity in asthmatic children.
Methods:
Asthmatic exacerbation children (N = 90), asthmatic remission children (N = 90), and healthy controls (N = 90) were enrolled in this case-control study, whose venous blood samples were collected after enrollment for routine blood test, JKAP, and inflammatory cytokines detection by enzyme-linked immune sorbent assay. The clinical features included demographic data, family history of asthma, and pulmonary ventilation function.
Results:
JKAP level was the lowest in asthmatic exacerbation children, followed by asthmatic remission children and healthy controls. ROC curve revealed good ability of JKAP in distinguishing three groups from each other, especially in telling asthmatic exacerbation children from healthy controls (AUC: 0.926; 95%CI: 0.887-0.965). In addition, JKAP was negatively correlated with eosinophil count, immunoglobulin E (IgE), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and interleukin-17 (IL-17), positively correlated with forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC) and FEV1 (%predicted) in asthmatic exacerbation children. Whereas in asthmatic remission children, JKAP was negatively correlated with eosinophil count, TNF-α, IL-1β, IL-6, and IL-17 and positively correlated with FEV1 (%predicted), but not with IgE or FEV1/FVC. In healthy controls, the correlation of JKAP with clinical features and inflammatory cytokines was non-obvious. For exacerbation severity, JKAP was the highest in mild exacerbation children, followed by moderate exacerbation children, and severe exacerbation children.
Conclusion:
JKAP serves as a potential biomarker for asthmatic susceptibility, inflammation, exacerbation risk, and severity in children.
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