Related Experiment Video
Updated: Dec 1, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
Published on: March 28, 2025
Advances in percutaneous coronary intervention for chronic total occlusions: current antegrade dissection and reentry
T Berkhout1, B E Claessen2, M T Dirksen2
1Department of Cardiology, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands. t.berkhout@nwz.nl.
Insights
The hybrid algorithm, including antegrade dissection and reentry (ADR), improves success rates for complex percutaneous coronary intervention (PCI) in chronic total occlusions (CTO). This review presents an updated ADR algorithm to aid operators in challenging CTO procedures.
Area of Science:
- Interventional Cardiology
- Vascular Surgery
Background:
- Percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) presents significant challenges, often associated with low success and high complication rates.
- The hybrid algorithm has emerged as a strategy to improve PCI outcomes in CTO cases.
- Antegrade dissection and reentry (ADR) is a critical component of the hybrid algorithm, enabling guidewire passage within the subintimal space to restore antegrade blood flow.
Purpose of the Study:
- To review recent advancements in materials and techniques for antegrade dissection and reentry (ADR) in PCI for chronic total occlusions (CTO).
- To present an updated ADR algorithm to assist interventional cardiologists in performing complex CTO procedures.
Main Methods:
- Review of contemporary literature on ADR techniques and associated technologies for CTO intervention.
- Development of a revised ADR algorithm based on recent innovations and clinical experience.
Main Results:
- Antegrade dissection and reentry (ADR) significantly enhances success rates in complex CTO interventions.
- New materials and techniques introduced over the last decade have refined ADR procedures.
- The updated ADR algorithm provides a structured approach for operators during CTO interventions.
Conclusions:
- The hybrid algorithm, incorporating ADR, is effective in increasing success rates for PCI in CTO with acceptable complications.
- Continuous innovation in ADR technology supports improved outcomes for challenging CTO cases.
- The presented updated ADR algorithm serves as a valuable resource for CTO operators.
Abstract:
Percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) is considered relatively complex with low success rates and high complication rates. Treating a CTO with PCI using the hybrid algorithm increases success rates with acceptable complication rates. An essential part of the hybrid algorithm is antegrade dissection and reentry (ADR). In PCI of a non-CTO coronary lesion, the guidewire over which the stent is advanced and placed stays within the true lumen of the coronary artery. ADR techniques make it possible to cross the lesion through the wall of the coronary artery, the subintimal space, thus creating a small bypass within the architecture of the coronary artery and restoring antegrade blood flow. ADR increases success rates, especially in more difficult CTO procedures. In the last decade, new materials and techniques have been introduced in quick succession, which are summarised in this review. Consequently an updated ADR algorithm is presented, which can support the CTO operator during an ADR procedure.
More Related Videos
06:30Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock
Published on: May 19, 2022
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Acute Coronary Syndrome I: Introduction
Angina IV: Management