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Updated: Jul 27, 2026
09:45
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
Cancer genes, proto-oncogenes, and development.
R I Ohlsson1, S B Pfeifer-Ohlsson
1Centre for Biotechnology, Karolinska Institute, Huddinge University Hospital, Sweden.
Experimental Cell Research
|November 1, 1987
Summary
Retroviral cancer genes disrupt cellular development. Understanding this interaction helps identify developmental controls and targets for cancer-causing agents.
Area of Science:
- Molecular Biology
- Developmental Biology
- Oncology
Background:
- Retroviral cancer genes are known to disrupt normal cellular development.
- Proto-oncogenes play a critical role in cellular growth and differentiation.
Purpose of the Study:
- To investigate the interplay between cancer genes and developmental processes.
- To identify key developmental controls that can be targeted by oncogenic agents.
Main Methods:
- Observational studies on retroviral gene function.
- Analysis of proto-oncogene roles in development.
Main Results:
- Retroviral cancer genes interfere with the developmental programs of target cells.
- The interface between cancer genes and development is a critical area of research.
Conclusions:
- Understanding the interaction between cancer genes and development is crucial for both delineating developmental controls and identifying targets for oncogenic agents.
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