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Prognostic value of liver biochemical parameters for COVID-19 mortality

Lin Ye1, Bin Chen2, Yitong Wang3

  • 1Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Annals of Hepatology
|November 6, 2020
PubMed

Insights

Liver function tests, including aspartate aminotransferase (AST), alanine transaminase (ALT), total bilirubin (TBIL), lactic dehydrogenase (LDH), and albumin (ALB), are strongly linked to COVID-19 patient survival. Abnormal liver enzyme levels indicate a higher risk of mortality in COVID-19 patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Clinical Biochemistry

Background:

  • Coronavirus disease 2019 (COVID-19) poses significant global public health challenges.
  • Limited comprehensive analyses exist on the association between liver biochemical parameters and COVID-19 mortality.

Purpose of the Study:

  • To conduct a meta-analysis investigating the relationship between liver biochemical parameters and COVID-19 mortality.
  • To determine if specific liver enzyme levels can predict prognosis in COVID-19 patients.

Main Methods:

  • Systematic literature search of multiple electronic databases (PubMed, Embase, Cochrane Library, Web of Science, Scopus, Wanfang, CNKI) until May 5, 2020.
  • Meta-analysis and statistical analyses were performed using STATA software.
  • Included 25 studies with 5971 COVID-19 patients.

Main Results:

  • Survivors exhibited significantly lower levels of AST, ALT, TBIL, and LDH, and higher ALB levels compared to non-survivors.
  • Lower proportions of abnormal AST, ALT, TBIL, LDH, and ALB were observed in survivors.
  • Sensitivity analyses and Egger's test confirmed the robustness of the findings and absence of publication bias.

Conclusions:

  • Liver biochemical parameters are significantly correlated with COVID-19 mortality.
  • Monitoring liver function tests can aid clinicians in assessing the prognosis of COVID-19 patients.
  • These findings highlight the importance of liver health in the context of COVID-19 outcomes.
Abstract

Keywords:
COVID-19Liver biochemical parametersMeta-analysisMortality

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