Risk factors associated with disease aggravation among 126 hospitalized patients with COVID-19 in different places in
Shuai Shao1,2,3, Zhiling Zhao1,2,3, Feng Wang1,2,3
1Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University.
Insights
Older age, dyspnea, low total protein, and low albumin are key risk factors for severe COVID-19. Early monitoring and intervention for these indicators can help prevent disease progression.
Area of Science:
- Infectious Diseases
- Epidemiology
- Clinical Medicine
Background:
- Coronavirus disease 2019 (COVID-19) has caused a global pandemic.
- Identifying risk factors for severe COVID-19 is crucial for patient management.
Purpose of the Study:
- To identify clinical and laboratory risk factors associated with severe COVID-19.
- To differentiate severe COVID-19 from the common type.
Main Methods:
- Retrospective study of 126 COVID-19 patients in Wuhan and Zhoukou.
- Classification into severe and common groups based on admission guidelines.
- Comparison of clinical manifestations and laboratory tests using univariate and multivariate logistic regression.
Main Results:
- Severe COVID-19 patients were older and had higher rates of dyspnea, weakness, diarrhea, hypertension, and coinfection.
- Laboratory findings in severe cases included increased neutrophils, C-reactive protein, procalcitonin, and decreased lymphocytes, hemoglobin, total protein (TP), and albumin (ALB).
- Logistic regression identified dyspnea, TP, and ALB as independent risk factors for severe disease.
Conclusions:
- Dyspnea, low total protein, and low albumin are significant independent risk factors for severe COVID-19.
- Close monitoring and early intervention for patients with these indicators are recommended to prevent severe disease progression.
Abstract:
Coronavirus disease 2019 (COVID-19) has rapidly spread on a global scale. Therefore, it is urgent to identify risk factors that could be associated with severe type of COVID-19 from common type.For this retrospective study, we recruited patients with COVID-19 in Wuhan and Zhoukou. Patients were classified into a severe group and common group based on guidelines after admission. Clinical manifestations and laboratory tests were compared, and univariate binary logistic regression and multivariate regression analyses were applied to assess potential risk factors.A total of 126 patients were recruited from January 23 to March 23, 2020. Ninety cases were identified as the common type and 36 as the severe type. The average age in the severe group was significantly older than that in the common group (P = .008). Patients with severe COVID-19 exhibited higher proportions of dyspnea (P = .001), weakness (P = .023), and diarrhea (P = .046). Moreover, there were more patients with hypertension (P = .01) or coinfection (P = .001) in the severe group than in the common group. Additionally, severe COVID-19 was associated with increased neutrophil counts (P < .001), C-reactive protein (P < .001), procalcitonin (P = .024) and decreased lymphocyte counts (P = .001), hemoglobin (P < .001), total protein (TP) (P < .001), and albumin (ALB) (P < .001). Based on logistic regression analysis, dyspnea (P < .001), TP (P = .042), and ALB (P = .003) were independent risk factors for severe disease.Patients with lower TP, ALB, and dyspnea should be carefully monitored, and early intervention should be implemented to prevent the development of severe disease.
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