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Updated: Dec 1, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Predictive value of MEP1A in cancer prognosis: A protocol for systematic review and meta-analysis
Yong Chen1, Fangfang Wu2, Li Zhang3
1The First Hospital of Lanzhou University.
Background:
Meprin is a member of the astaxanthin family; it performs many functions through a wide range of proteolytic enzyme activities during health and disease, including tumors and inflammatory conditions. The purpose of this systematic review was to evaluate the predictive value of MEP1A in tumor prognosis.
Methods:
A comprehensive search was conducted on PubMed, Cochrane library, and Web of Science Database using a developed search strategy. The Newcastle-Ottawa Scale (NOS) or the Cochrane Collaboration's tool for assessing risk of bias will be used to access the methodological quality of included studies, and GRADE will be applied to evaluate evidence quality of outcomes. All analyses were performed by Stata 15.0.
Results:
The results will systematically summarize and display the currently collected evidence on the predictive value of MEP1A in different tumor prognosis.
Conclusion:
This study may play a certain role in predicting the prognosis of cancer patients in the future, and may prompt clinicians to make necessary treatment or prevention plans as soon as possible.
Ethics And Communication:
It is not necessary because the present systematic review is based on published studies.
Inplasy Registration Number:
INPLASY2020100005.
Insights
This systematic review evaluates the predictive value of Meprin A (MEP1A) in tumor prognosis. Findings may aid clinicians in developing timely cancer patient treatment and prevention strategies.
Area of Science:
- Biochemistry
- Oncology
- Protease research
Background:
- Meprin A (MEP1A) is a proteolytic enzyme involved in various physiological and pathological processes, including cancer.
- Its role in tumor progression and patient outcomes requires further elucidation.
Purpose of the Study:
- To systematically review and evaluate the predictive significance of MEP1A in tumor prognosis.
- To synthesize current evidence on MEP1A's association with cancer outcomes.
Main Methods:
- Comprehensive literature search across PubMed, Cochrane Library, and Web of Science.
- Methodological quality assessed using Newcastle-Ottawa Scale (NOS) or Cochrane's risk of bias tool.
- Evidence quality evaluated using GRADE criteria; data analyzed with Stata 15.0.
Main Results:
- Systematic summarization and presentation of existing evidence on MEP1A's predictive value in diverse tumor prognoses.
- Quantitative and qualitative synthesis of study findings related to MEP1A and cancer outcomes.
Conclusions:
- MEP1A holds potential as a prognostic biomarker in oncology.
- Findings may inform clinical decision-making for cancer patient management and early intervention.
