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Ascorbic acid supplementation in type 2 diabetes mellitus: A protocol for systematic review and meta-analysis
Lipeng Shi1, Xuqin Du2, Pei Guo3
1Clinical Department, Dianjiang Hospital of Traditional Chinese Medicine, Dianjiang, Chongqing.
Ascorbic acid supplementation may benefit type 2 diabetes patients by improving blood glucose control and insulin resistance. This meta-analysis synthesizes high-quality trials to confirm its efficacy and safety.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Nutritional Science
Background:
- Type 2 diabetes mellitus (T2DM) is a growing global health concern.
- Ascorbic acid (vitamin C) shows potential in managing T2DM by influencing glucose metabolism and insulin sensitivity.
- Existing research is limited by small sample sizes and study quality, necessitating a robust meta-analysis.
Purpose of the Study:
- To systematically evaluate the efficacy and safety of ascorbic acid supplementation in T2DM patients.
- To provide high-quality evidence on ascorbic acid's impact on glycemic control and insulin resistance.
Main Methods:
- Comprehensive literature search of major databases (PubMed, Embase, Cochrane, Web of Science, ClinicalTrials.gov) up to August 2020.
- Inclusion of randomized controlled trials (RCTs) with no language restrictions.
- Data extraction and meta-analysis using Review Manager software (V5.3.0).
Main Results:
- A high-quality, in-depth analysis of ascorbic acid's effects on key T2DM markers.
- Focus on blood glucose, glycosylated hemoglobin, and insulin resistance in T2DM patients.
Conclusions:
- This meta-analysis will offer strong evidence regarding ascorbic acid's benefits for T2DM glucose control and insulin resistance.
- Findings will guide future clinical practice and research directions for T2DM management with ascorbic acid.
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