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Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
Lina Zhao1, Lijiao Zhao2, Yun Ying Wang1
1Department of Critical Care Medicine, Chifeng Municipal Hospital, Inner Mongolia.
Medicine
|November 7, 2020
Summary
Platelet count abnormalities predict long-term survival in sepsis patients. A new nomogram using platelet levels and other factors accurately forecasts 1-year survival, aiding clinical decisions.
Area of Science:
- Hematology
- Critical Care Medicine
- Biostatistics
Background:
- Platelet dysfunction is a known factor in sepsis-induced organ damage.
- Limited research exists on the impact of platelet function on long-term sepsis outcomes.
- Understanding these long-term effects is crucial for patient management.
Purpose of the Study:
- To investigate the role of platelets in the long-term prognosis of sepsis patients.
- To develop a predictive model for 1-year overall survival (OS) in sepsis.
Main Methods:
- Retrospective analysis of 4576 sepsis patients from the MIMIC III Database.
- Kaplan-Meier survival analysis, univariate and multivariate Cox regression.
- Development and validation of a nomogram for predicting 1-year OS using prognostic factors.
Main Results:
- Abnormal platelet levels correlated with poorer patient prognosis.
- Age, blood urea nitrogen, platelets, INR, PTT, potassium, hemoglobin, WBC count, and organ failures were independent predictors of 1-year OS.
- The developed nomogram demonstrated robust discrimination (AUC=0.752) and optimal calibration.
Conclusions:
- Platelet count is an independent predictor of 1-year OS in sepsis patients.
- A novel platelet-related nomogram can effectively predict 1-year OS in sepsis.
- The nomogram exhibits clinical utility due to its strong predictive accuracy and calibration.
