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Management of intussusception in children: A systematic review
Lorraine I Kelley-Quon1, L Grier Arthur2, Regan F Williams3
1Division of Pediatric Surgery, Children's Hospital Los Angeles and the Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Insights
For children with ileocolic intussusception, pre-reduction antibiotics are not needed. Outpatient management and minimally invasive techniques are recommended for stable patients.
Area of Science:
- Pediatric Surgery
- Gastroenterology
Background:
- Ileocolic intussusception is a common surgical emergency in children.
- Current management strategies vary, necessitating evidence-based recommendations.
Purpose of the Study:
- To develop clinical recommendations for managing pediatric ileocolic intussusception.
- To synthesize evidence on antibiotic use, enema reduction, outpatient care, and surgical techniques.
Main Methods:
- Systematic review of literature from January 1988 to December 2018.
- Searched ClinicalTrials.gov, Embase, PubMed, and Scopus databases.
- Followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.
Main Results:
- 83 articles were reviewed.
- Prophylactic antibiotics did not reduce complications after radiologic reduction.
- Outpatient observation post-enema reduction is safe; laparoscopic reduction is often successful.
Conclusions:
- Pre-reduction antibiotics are unnecessary for stable children.
- Maximize non-operative outpatient management.
- Consider minimally invasive techniques to avoid laparotomy.
Objective:
The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to develop recommendations for the management of ileocolic intussusception in children.
Methods:
The ClinicalTrials.gov, Embase, PubMed, and Scopus databases were queried for literature from January 1988 through December 2018. Search terms were designed to address the following topics in intussusception: prophylactic antibiotic use, repeated enema reductions, outpatient management, and use of minimally invasive techniques for children with intussusception. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were followed. Consensus recommendations were derived based on the best available evidence.
Results:
A total of 83 articles were analyzed and included for review. Prophylactic antibiotic use does not decrease complications after radiologic reduction. Repeated enema reductions may be attempted when clinically appropriate. Patients can be safely observed in the emergency department following enema reduction of ileocolic intussusception, avoiding hospital admission. Laparoscopic reduction is often successful.
Conclusions:
Regarding intussusception in hemodynamically stable children without critical illness, pre-reduction antibiotics are unnecessary, non-operative outpatient management should be maximized, and minimally invasive techniques may be used to avoid laparotomy.
Level Of Evidence:
Level 3-5 (mainly level 3-4) TYPE OF STUDY: Systematic Review of level 1-4 studies.
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