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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Primary cardiac lymphoma.

Kanhua Yin1, Hilliard Brydges2, Kyle W Lawrence2

  • 1Division of Cardiac Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass; Harvard T. H. Chan School of Public Health, Boston, Mass.

The Journal of Thoracic and Cardiovascular Surgery
|November 7, 2020
PubMed
Summary
This summary is machine-generated.

Surgical resection does not improve survival for primary cardiac lymphoma patients. Chemotherapy is the primary treatment, significantly improving survival, while older age and advanced stage worsen outcomes.

Keywords:
SEERprimary cardiac lymphomasurgical resectionsurvivaltreatment modality

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Area of Science:

  • Oncology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Primary cardiac lymphoma is a rare malignancy with limited understanding of population-level treatment outcomes.
  • Surgical resection is sometimes considered, but its survival benefit remains unclear.

Purpose of the Study:

  • To analyze treatment modalities for primary cardiac lymphoma.
  • To evaluate the survival impact of surgical resection in this patient population.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973-2015).
  • Included patients with a histologic diagnosis of primary cardiac lymphoma.
  • Employed multivariable accelerated failure time regression to assess survival predictors.

Main Results:

  • 184 patients were identified; diffuse large B-cell lymphoma was most common (80%).
  • Chemotherapy was administered to 73%, while only 10% underwent surgical resection.
  • Surgical resection showed no independent survival benefit (aHR 0.67), but chemotherapy did (aHR 0.4).
  • Increasing age and advanced stage were associated with worse survival.

Conclusions:

  • Surgical resection is not independently associated with improved survival in primary cardiac lymphoma.
  • Chemotherapy is a key treatment modality linked to better survival outcomes.
  • Age and disease stage are critical prognostic factors influencing patient survival.