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Demonstration of pepsinogen C in human pancreatic islets

P B Szecsi1, H Halgreen, S S Poulsen

  • 1Department of Clinical Chemistry, Hvidovre Hospital, Denmark.

Gut
|October 1, 1987
PubMed

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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