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Related Experiment Video

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Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-Term Memory.

Yasir Gallero-Salas1, Shuting Han2, Yaroslav Sych2

  • 1Brain Research Institute, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, Zurich, Switzerland.

Neuron
|November 7, 2020
PubMed
Summary

Behavior, not sensory input, dictates where short-term memory signals are stored in the brain. This study reveals how active or passive behavior directs neural activity in the posterior parietal cortex (PPC) for memory tasks.

Keywords:
association cortexauditory cortexbarrel cortexbehavioral strategymotor cortexmouseposterior parietal cortexshort-term memorywide-field calcium imaging

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cognitive Neuroscience

Background:

  • Sensory information processing in the neocortex involves distinct pathways to association areas.
  • The convergence points for short-term memory and the influence of behavior on signal routing are not well understood.

Purpose of the Study:

  • To investigate how behavior influences cortical signal flow during short-term memory tasks.
  • To identify brain regions involved in maintaining sensory information for delayed responses.
  • To explore the interplay between sensory modality and behavioral strategy in neural activity.

Main Methods:

  • Utilized wide-field calcium imaging to monitor cortex-wide neuronal activity in layer 2/3 of mouse brains.
  • Compared neural activity during auditory and tactile delayed response tasks.
  • Manipulated behavioral strategy by having mice be either active or passive during stimulus presentation.

Main Results:

  • Auditory and tactile stimuli activated distinct subdivisions of the posterior parietal cortex (PPC), namely anterior area A and rostrolateral area RL, respectively.
  • During the delay period, short-term memory location was determined by behavioral strategy, not sensory modality.
  • Neural activity converged frontomedially in active trials and posterolaterally in passive trials during the delay period.

Conclusions:

  • Behavioral strategy significantly influences the routing of sensory information within the cortex.
  • Sensory-specific information is initially processed in distinct PPC subdivisions.
  • Signal flow shifts to different association areas based on behavioral state for short-term memory maintenance.