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Updated: Dec 1, 2025
One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided
Xiaoting Gao1, Shanshan Jiang2, Chunying Li1
1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, 325000, China; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China.
Abstract:
The development of tumor acidic microenvironment-responsive theranostic agents is a research hotspot. Herein, we developed highly photostable amphiphilic croconium dye-anchored red blood cell membrane vesicle (denoted as LET-5) for tumor pH-responsive near-infrared fluorescence (NIRF) and photoacoustic (PA) duplex imaging-guided photothermal therapy. In tumor acidic microenvironment, both NIRF and PA signals of LET-5 were significantly enhanced and the photothermal effect of LET-5 was activated. Notably, cell membrane-based vesicle with enhanced stability and long blood circulation significantly improved the tumor accumulation of croconium dye, thus achieving better therapeutic effect than free croconium dye. These findings provide a promising approach to construct amphiphilic dye-anchored cell membrane vesicle for cancer theranostics.
Insights
Researchers created a novel red blood cell membrane vesicle loaded with croconium dye (LET-5) that targets tumors. This agent enhances imaging and photothermal therapy in acidic tumor environments, improving cancer treatment outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- The tumor acidic microenvironment presents a significant challenge in cancer theranostics.
- Developing responsive agents for enhanced tumor imaging and therapy is crucial.
Purpose of the Study:
- To develop a pH-responsive theranostic agent for enhanced cancer imaging and therapy.
- To utilize red blood cell membrane vesicles for improved drug delivery and stability.
Main Methods:
- Synthesized amphiphilic croconium dye-anchored red blood cell membrane vesicles (LET-5).
- Evaluated LET-5 for pH-responsive near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging.
- Assessed the photothermal therapy efficacy of LET-5 in acidic tumor environments.
Main Results:
- LET-5 exhibited enhanced NIRF and PA signals in acidic conditions.
- The photothermal effect of LET-5 was activated in the tumor microenvironment.
- LET-5 demonstrated improved tumor accumulation and therapeutic efficacy compared to free croconium dye.
Conclusions:
- LET-5 serves as a promising theranostic agent for tumor pH-responsive imaging and therapy.
- Amphiphilic dye-anchored cell membrane vesicles offer a viable strategy for cancer theranostics.
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