Anti-NMDAR encephalitis may develop concurrently with anti-MOG antibody-associated bilateral medial frontal cerebral
Juichi Fujimori1, Toshiyuki Takahashi2, Kimihiko Kaneko3
1Division of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Abstract:
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may develop concurrently with or separate from episodes of demyelinating disorders. Previously, we reported a patient with relapsing anti-NMDAR encephalitis who had presented with bilateral medial frontal cerebral cortical lesions at onset. Recently, we assessed CSF anti-myelin oligodendrocyte glycoprotein (MOG) antibody for the first time in this case and found that the patient had been double positive for anti-NMDAR and anti-MOG antibodies from onset. The two antibody titres, CSF cells, IL-6 and CXCL13 were all elevated at onset. Anti-NMDAR encephalitis may develop concurrently with anti-MOG antibody-associated cortical encephalitis and relapse with elevated levels of CSF cytokines.
Insights
This study found that anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis can co-occur with anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis. Elevated antibody levels and cytokines were observed at the onset of this dual-antibody condition.
Area of Science:
- Neuroimmunology
- Neurology
- Autoimmune Encephalitis
Background:
- Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder. Demyelinating disorders can occur independently or alongside NMDAR encephalitis. Previously, a patient with relapsing anti-NMDAR encephalitis and specific cerebral lesions was reported.
- This case highlights a potential co-occurrence of anti-NMDAR encephalitis and anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated conditions.
More Related Videos
07:20A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
08:20Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022