Postoperative pancreatic fistulas decrease the survival of pancreatic cancer patients treated with surgery after
Yuichiro Uchida1, Toshihiko Masui2, Kazuyuki Nagai2
1Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Hospital, Japan; Department of Surgery, Fujita Medical University Hospital, Japan.
Background And Objectives:
A postoperative pancreatic fistula (POPF) is a critical complication after surgery for pancreatic cancer. Whether a POPF affects the long-term prognosis of pancreatic cancer cases remains controversial. This study aimed to clarify the effect of a POPF on the long-term prognosis of pancreatic cancer patients, especially after neoadjuvant chemoradiotherapy (NACRT).
Methods:
Patients who underwent curative pancreatectomy for pancreatic cancer between January 2012 and June 2019 at Kyoto University Hospital were retrospectively investigated. A fistula ≥ Grade B was considered a POPF.
Results:
During the study period, 148 patients underwent upfront surgery (Upfront group), and 52 patients underwent surgery after NACRT (NACRT group). A POPF developed in 16% of patients in the Upfront group and 13% in the NACRT group (p = 0.824). In the Upfront group, development of a POPF did not have a significant effect on recurrence-free survival (p = 0.766) or overall survival (p = 0.863). However, in the NACRT group, development of a POPF significantly decreased recurrence-free survival (HR 5.856, p = 0.002) and overall survival (HR 7.097, p = 0.020) on multivariate analysis.
Conclusions:
The development of a POPF decreases the survival of pancreatic cancer patients treated by surgery after NACRT.
