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Updated: Dec 1, 2025
The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
Published on: February 7, 2025
On the Improper Use of the Term High-Density Neutrophils
Marco A Cassatella1, Patrizia Scapini1
1Department of Medicine, Section of General Pathology, Strada Le Grazie 4, 37138 Verona, University of Verona, Italy.
Abstract:
Recent studies have revealed that neutrophils exhibit an unsuspected heterogeneity. In this context, the term high-density neutrophils (HDNs) has recently gained ground to define nothing more than neutrophils displaying an unaltered normal density. Therefore, as discussed here, we argue that the HDNs term must be avoided, as it is confounding and scientifically inappropriate.
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