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Updated: Dec 1, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
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SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway

Tongshuai Chen1, Chang Ma1, Guanqi Fan2

  • 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Life Sciences
|November 8, 2020
PubMed

Keywords:
Endothelial senescenceHigh glucoseSIRT3p53

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