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Updated: Dec 1, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

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Extracellular vesicle-based therapeutics for the regeneration of chronic wounds: current knowledge and future

Peng Lou1, Shuyun Liu1, Xuewen Xu2

  • 1Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Acta Biomaterialia
|November 8, 2020
PubMed

Insights

Extracellular vesicles (EVs) show promise for chronic wound healing by aiding regeneration. Further research into EV-based therapies could revolutionize wound care.

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Wound Healing Research

Background:

  • Chronic wounds present a significant clinical challenge with limited regenerative capacity in current treatments.
  • Extracellular vesicles (EVs), natural nanovesicles from various cells, are crucial in all phases of skin wound repair.
  • EVs offer therapeutic potential for enhancing skin regeneration.

Purpose of the Study:

  • To review the biological roles of EVs in chronic wound healing.
  • To discuss current findings on EV applications in immune regulation, cell proliferation, angiogenesis, and extracellular matrix remodeling.
  • To explore therapeutic strategies involving EVs for chronic wound treatment.

Main Methods:

  • Review of existing scientific literature on extracellular vesicle biology and function in wound healing.
  • Analysis of studies investigating EV roles in inflammation, proliferation, and remodeling stages of wound repair.
  • Examination of therapeutic approaches utilizing genetically modified EVs, biomaterial combinations, and drug delivery systems.

Main Results:

  • EVs actively participate in immune modulation, cell migration, and angiogenesis during wound healing.
  • EVs promote extracellular matrix remodeling, essential for tissue regeneration.
  • Engineered EVs and EV-combined biomaterials demonstrate enhanced therapeutic effects on chronic wounds.

Conclusions:

  • Extracellular vesicles hold significant therapeutic potential for promoting chronic wound regeneration.
  • EV-based strategies, including genetic modification and biomaterial integration, offer promising avenues for advanced wound care.
  • Further investigation is needed to overcome challenges and translate EV therapies into clinical practice for chronic wound management.
Keywords:
AngiogenesisChronic woundExtracellular vesiclesInflammationProliferationRemodeling

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