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COVID-19 update: The race to therapeutic development
Julianne D Twomey1, Shen Luo1, Alexis Q Dean1
1Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States.
Summary
This review explores COVID-19 treatments, focusing on repurposed drugs like remdesivir and dexamethasone, and novel biologics targeting viral entry. It also discusses drug resistance and clinical trial design for managing SARS-CoV-2 infection.
Area of Science:
- Virology
- Infectious Diseases
- Pharmacology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, poses a significant global health challenge with millions of cases and deaths.
- Current COVID-19 management is primarily supportive, with ongoing research into various therapeutic interventions.
Purpose of the Study:
- To review recent advances in understanding SARS-CoV-2 pathobiology and identify potential therapeutic targets.
- To highlight current strategies for COVID-19 treatment, including drug repurposing and novel biological products.
Main Methods:
- Literature review of recent advances in SARS-CoV-2 pathobiology and therapeutic strategies.
- Analysis of drug repurposing (antivirals, immunomodulators) and novel biological products (neutralizing antibodies, soluble ACE2).
Main Results:
- Two main therapeutic strategies are discussed: repurposing existing drugs and developing novel biologics targeting viral entry.
- Novel approaches include neutralizing antibodies against the spike protein and recombinant soluble ACE2 protein.
Conclusions:
- Understanding SARS-CoV-2 pathobiology is crucial for developing effective treatments.
- Future research should address potential drug resistance mechanisms and optimize clinical trial designs for diverse COVID-19 manifestations.
Keywords:
ACE2AntiviralsCOVID-19Drug developmentExisting drugsImmunomodulatorsMonoclonal antibodiesRepurposed useSARS-CoV-2Spike proteinTherapeutic targetsVirus life cycleMore Related Videos
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