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Related Experiment Video

Updated: Dec 1, 2025

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Limited Lymph Node Resection Does Not Decrease Postoperative Mortality After Esophagectomy in Octogenarians With

Qiangming Li1, Senlin Zhu1, Shuaishuai Liu1

  • 1Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

The Journal of Surgical Research
|November 9, 2020
PubMed
Summary

For octogenarians with esophageal cancer, extensive lymph node dissection does not reduce postoperative mortality. Less extensive lymph node resection is not associated with improved survival outcomes in this age group.

Keywords:
Esophageal cancerLymph node dissectionOctogenarianSurveillance, Epidemiology, and End Results (SEER)

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Area of Science:

  • Oncology
  • Geriatric Surgery
  • Surgical Pathology

Background:

  • Octogenarians with esophageal cancer face high postoperative mortality (POM) due to poor physical condition and reduced reserves.
  • Extensive lymph node dissection in this population increases surgical trauma and complications.

Purpose of the Study:

  • To investigate the relationship between the number of dissected lymph nodes and short-term and long-term postoperative outcomes in octogenarians with thoracic esophageal cancer.

Main Methods:

  • Analysis of Surveillance, Epidemiology, and End Results database data from 208 octogenarians.
  • Patients were grouped by examined lymph nodes (eLNs): <15 eLNs vs. ≥15 eLNs.
  • Statistical analyses included logistic regression for mortality predictors and Kaplan-Meier for survival.

Main Results:

  • No statistically significant differences in 30, 60, or 90-day POM rates between the <15 eLNs and ≥15 eLNs groups.
  • Age and marital status were significant predictors of 90-day POM.
  • No significant differences in 5-year overall or cause-specific survival between the groups.

Conclusions:

  • Esophagectomy in octogenarians is associated with high POM, and less extensive lymph node resection does not reduce this risk.
  • Octogenarians may not benefit from esophagectomy with lymphadenectomy.
  • Further research is needed to guide selective esophagectomy in this demographic.