Related Experiment Video
Updated: Dec 1, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Multisystem Inflammatory Syndrome in Children
Sydney Tabaac1, Poonam Kothari1, Tara Cassidy-Smith1
1Department of Emergency Medicine, Cooper University Hospital, Camden, New Jersey.
Insights
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition associated with COVID-19, presenting with diverse symptoms. Early recognition by emergency physicians is crucial to prevent severe complications.
Area of Science:
- Pediatric infectious diseases
- Critical care medicine
- Cardiology
Background:
- Increasing global cases of COVID-19 have led to the identification of a rare associated condition in children.
- This condition is known as multisystem inflammatory syndrome in children (MIS-C).
- MIS-C presents with varied clinical manifestations including shock, Kawasaki-like disease, and coronary artery abnormalities.
Background:
As the number of coronavirus disease 2019 (COVID-19) cases increases globally, more cases of a rare COVID-19-associated disease process are being identified in the pediatric population. This syndrome is referred to as multisystem inflammatory syndrome in children (MIS-C). Clinical manifestations of the syndrome vary and include one or a combination of the following: vasodilatory shock, cardiogenic shock, Kawasaki-like disease, cytokine storming, coronary artery dilatation, and aneurysms.
Case Report:
This case report describes the presentation, findings, workup, and treatment for a 9-year-old boy diagnosed with MIS-C. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: It is important to recognize MIS-C, as it shares many of the same features as other disease processes, for example, Kawasaki disease and toxic shock syndrome, but has different complications if left untreated.
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Myocarditis II: Clinical Features and Diagnostic Tests
Nephrotic Syndrome I : Introduction

