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Updated: Dec 1, 2025

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
[Epstein-Barr virus infection and lymphoproliferative disorders]
1Department of Medical Oncology, Hematology and Infectious Diseases, Fukuoka University Hospital.
Abstract:
Epstein-Barr virus (EBV), the first human tumor virus, was discovered more than 55 years ago. Although EBV is carried by the majority of human population, it contributes to only a small subset of all human cancers. In individuals, this virus manifests lymphotropism, establishes latent infection, and eventually hides in resting memory B cells. However, persons who fail to maintain the virus in its latent state may develop EBV-driven lymphoproliferative disorders (LPDs) and lymphomas. B-cell LPDs and lymphomas occur predominantly in immunocompromised patients, whereas T/NK-cell LPDs and lymphomas mainly arise in immunocompetent individuals. Improved understanding of the biology of these LPDs and the role of EBV expands the potential of new therapy targeting EBV-specific molecules.
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