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Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and
Karn Wijarnpreecha1, Panadeekarn Panjawatanan2, Paul T Kroner1
1Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA (Karn Wijarnpreecha, Paul T. Kroner).
Insights
Patients with nonalcoholic fatty liver disease (NAFLD) have a significantly higher risk of cardiac conduction defects. This finding highlights a crucial link between liver health and heart function that warrants further clinical investigation.
Area of Science:
- Cardiology
- Hepatology
- Public Health
Background:
- Nonalcoholic fatty liver disease (NAFLD) is frequently associated with cardiovascular diseases like coronary artery disease and congestive heart failure.
- The relationship between NAFLD and cardiac conduction defects remains understudied.
- Existing research indicates a potential link between NAFLD and adverse cardiac outcomes.
Purpose of the Study:
- To systematically review and meta-analyze existing studies on the association between NAFLD and cardiac conduction defects.
- To quantify the risk of cardiac conduction defects in individuals with NAFLD compared to those without.
- To provide a comprehensive summary of current evidence on this topic.
Main Methods:
- A systematic literature search was performed using MEDLINE and EMBASE databases up to June 2020.
- Included studies compared the risk of cardiac conduction defects in patients with and without NAFLD.
- Data were synthesized using a random-effect, generic inverse variance meta-analysis.
Main Results:
- Three cross-sectional studies involving 3651 participants met the inclusion criteria.
- Patients with NAFLD demonstrated a significantly higher risk of cardiac conduction defects.
- The pooled odds ratio for cardiac conduction defects in NAFLD patients was 5.17 (95% CI 1.34-20.01), with high heterogeneity (I² 96%).
Conclusions:
- This meta-analysis reveals a substantially increased risk of cardiac conduction defects among individuals with NAFLD.
- The clinical implications and management strategies for this elevated risk require further research.
- The findings underscore the importance of considering cardiac health in NAFLD patients.
Background:
Cardiovascular disease is a common comorbidity of patients with nonalcoholic fatty liver disease (NAFLD), particularly coronary artery disease and congestive heart failure. However, the relation between NAFLD and cardiac conduction defects has not been well studied. This systematic review and meta-analysis was conducted to identify all available studies on this association and summarize their results.
Methods:
A comprehensive literature review was conducted using MEDLINE and EMBASE databases through June 2020 to identify studies that compared the risk of a cardiac conduction defect among patients with NAFLD versus those without. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results:
Three cross-sectional studies with 3651 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of a cardiac conduction defect was significantly higher among patients with NAFLD than in those without NAFLD, with a pooled odds ratio of 5.17 (95% confidence interval 1.34-20.01; I 2 96%).
Conclusion:
A significantly greater risk of cardiac conduction defects among patients with NAFLD was observed in this meta-analysis. How this risk should be managed in clinical practice requires further investigation.
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