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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Updated: Dec 1, 2025

Models of Bone Metastasis
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Models of Bone Metastasis

Published on: September 4, 2012

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Osteocytes and Bone Metastasis.

Manuel A Riquelme1, Eduardo R Cardenas1, Jean X Jiang1

  • 1Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.

Frontiers in Endocrinology
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Osteocytes, the most abundant bone cells, play a crucial role in inhibiting cancer metastasis. Research highlights their potential to release anti-cancer factors, impacting bone health and tumor growth.

Keywords:
bonecancermetastasismicroenvironmentosteocyte

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Area of Science:

  • Oncology
  • Bone Biology
  • Cancer Metastasis

Background:

  • Bone is a primary site for metastasis of breast, prostate, and other solid tumors, posing significant treatment challenges.
  • Cancer cells exploit the bone microenvironment, creating a 'vicious cycle' that disrupts bone integrity and promotes tumor growth.
  • Osteocytes, the most abundant bone cells, are key regulators of bone homeostasis and interact with cancer cells.

Purpose of the Study:

  • To review recent research on the role of osteocytes in bone metastasis.
  • To provide mechanistic insights into how osteocytes influence the bone microenvironment during cancer colonization.
  • To explore osteocyte-mediated mechanisms that inhibit cancer cell growth and migration within bone.

Main Methods:

  • Review of current scientific literature on bone metastasis and osteocyte function.
  • Analysis of studies investigating the interaction between cancer cells and the bone microenvironment.
  • Examination of research on osteocyte-derived factors and their effects on cancer cells and bone remodeling.

Main Results:

  • Cancer cells can induce osteoblastic or osteolytic lesions, disrupting bone integrity and promoting tumor progression.
  • Osteocytes influence bone homeostasis and can exert anti-cancer effects, such as inhibiting osteoclast activity.
  • Exercise has been shown to stimulate osteocytes to release factors that inhibit metastasis and promote cancer cell dormancy.

Conclusions:

  • Osteocytes are critical regulators of the bone microenvironment and play a significant role in controlling cancer metastasis.
  • Understanding osteocyte-cancer cell interactions offers potential therapeutic strategies for managing bone metastasis.
  • Further research into osteocyte-derived factors could lead to novel treatments for bone cancers.