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Updated: Dec 1, 2025

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
Oral Neutrophils: Underestimated Players in Oral Cancer
Maksim Domnich1, Jana Riedesel1, Ekaterina Pylaeva1
1Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Abstract:
The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors.
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