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Updated: Dec 1, 2025
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients
Fadwah M Al-Sharif1, Shehab M Abd El-Kader2, Ziyad A Neamatallah2
1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Background:
Activation of immunological and systemic inflammation markers are common in obesity and asthma.
Objective:
The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.
Material And Methods:
Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 ± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).
Results:
The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.
Conclusion:
Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.
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