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Cole Relaxation Frequency as a Prognostic Parameter for Breast Cancer.

William D Gregory^1,2, Shahila Mehboob Christie¹, John Shell¹

¹NovaScan, Inc., Milwaukee, WI.

Journal of Patient-Centered Research and Reviews

|November 9, 2020

Summary

Cole relaxation frequency shows promise as a prognostic biomarker for breast cancer recurrence and metastasis. Higher frequencies correlate with increased cancer recurrence and spread, suggesting its potential for future patient outcome prediction.

Keywords:

Cole relaxation frequency bioelectrical impedance breast cancer prognosis recurrence

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Area of Science:

Oncology
Biophysics
Medical Diagnostics

Background:

Previous research established Cole relaxation frequency for classifying breast cancer vs. benign tissue.
A retrospective analysis of a prior study cohort was conducted.

Purpose of the Study:

To investigate the prognostic potential of Cole relaxation frequency for breast cancer patient outcomes.
To correlate Cole relaxation frequency with cancer recurrence and metastasis status.

Main Methods:

Utilized health system cancer registry data for retrospective outcome classification.
Categorized patient outcomes into nonrecurrent (NR), recurrent with no metastasis (RNM), and recurrent with metastasis (RM).
Performed multivariate analysis to assess the association between Cole relaxation frequency and time-cancer-free.

Main Results:

Cole relaxation frequency demonstrated a clear trend from nonrecurrent to recurrent with metastasis.
Increased Cole relaxation frequency significantly correlated with poorer patient outcomes.
Multivariate analysis revealed significant associations (P-values 0.0001-0.0047) with time-cancer-free.

Conclusions:

Cole relaxation frequency is a feasible prognostic parameter for breast cancer.
This finding supports its use in larger, prospective studies for predicting patient prognosis.