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Corticosteroids in inflammatory bowel disease. A review
1Department of Medicine, University of Colorado School of Medicine, Denver 80262.
Journal of Clinical Gastroenterology
|October 1, 1987
Summary
Corticosteroids are widely used for inflammatory bowel disease (IBD). This review explores their immunologic actions and potential effects on IBD immunopathology, offering insights into their therapeutic mechanisms.
Area of Science:
- Immunology
- Gastroenterology
- Pharmacology
Background:
- Corticosteroids have a long history in treating inflammatory bowel disease (IBD).
- Clinical responses to corticosteroids in IBD are well-documented.
- However, their precise impact on the disease's immunopathology remains less understood.
Purpose of the Study:
- To review the known immunologic actions of corticosteroids.
- To discuss their effects on eicosanoid production and immune responses.
- To speculate on their specific immunologic effects in IBD.
Main Methods:
- Literature review of immunologic actions of corticosteroids.
- Analysis of effects on eicosanoid production.
- Examination of modulation of humoral and cellular immunity.
Main Results:
- Corticosteroids impact eicosanoid production.
- They modulate both humoral and cellular immune responses.
- Specific immunologic effects in IBD are inferred from general actions.
Conclusions:
- Corticosteroids exert significant immunologic effects relevant to IBD.
- Understanding these mechanisms can refine IBD treatment strategies.
- Further research is needed to fully elucidate corticosteroid's role in IBD immunopathology.