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Lipid-derived Compounds in the Human Body

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Updated: Dec 1, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Oxidized Lipids and Lipoprotein Dysfunction in Psoriasis.

Alexander V Sorokin1, Alan T Remaley1, Nehal N Mehta2

  • 1Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Journal of Psoriasis and Psoriatic Arthritis
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Psoriatic inflammation drives lipid oxidation, increasing cardiovascular disease (CVD) risk. Managing this link requires further research into dyslipidemia and novel cardiometabolic markers.

Keywords:
dyslipidemiainflammationlipoproteinsoxidationoxidized lipidspsoriasis

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Area of Science:

  • Dermatology
  • Cardiology
  • Metabolic Syndrome

Background:

  • Psoriasis is a chronic inflammatory skin disease linked to metabolic issues like obesity, dyslipidemia, and elevated cardiovascular disease (CVD) risk.
  • Shared pathways include immune activation, chronic inflammation, and lipoprotein dysfunction with lipid oxidative damage.

Purpose of the Study:

  • To review evidence linking psoriatic inflammation, lipid oxidation, and increased CVD risk.

Main Methods:

  • Systematic review of articles and original research from 1980-2020.
  • Keywords: psoriasis, oxidized lipids, oxidation, dyslipidemia, inflammation.

Main Results:

  • Psoriasis-associated inflammation increases pro-inflammatory oxidized lipids (omega-6 derived) and impairs resolution.
  • Sustained inflammation leads to excessive lipid oxidation, creating proatherogenic oxidized lipoproteins.
  • These mechanisms contribute to the heightened CVD risk in psoriasis patients.

Conclusions:

  • Anti-inflammatory treatments show promise for psoriasis but require more research for associated dyslipidemia.
  • Novel cardiometabolic markers for skin and vascular pathology are needed.