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Nanoarchitecting Hierarchical Mesoporous Siliceous Frameworks: A New Way Forward
Ranjith Kumar Kankala1,2,3, Shi-Bin Wang1,2,3, Ai-Zheng Chen1,2,3
1College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, P. R. China.
Iscience
|November 9, 2020
Summary
Re-engineering mesoporous silica nanoparticles (MSNs) addresses limitations like poor drug loading and toxicity. Modified MSNs offer complex, adaptable architectures for improved biomedical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Mesoporous silica nanoparticles (MSNs) possess desirable properties for various applications.
- However, MSNs face challenges including poor drug encapsulation, biocompatibility issues, and unpredictable toxicity.
- These limitations hinder their full potential in medical applications.
Purpose of the Study:
- To review advancements in re-engineering mesoporous silica nanoparticles.
- To highlight strategies for modifying MSN structures and properties.
- To explore the development of complex hetero-nanostructures.
Main Methods:
- Incorporation of organic and inorganic species into MSN frameworks.
- Modification of processing and formulation parameters.
- Design of irregular-shaped (Janus, multi-podal) and dynamically-modulated architectures.
Main Results:
- Development of complex hetero-nanostructures with high morphological complexity.
- Creation of adaptable, deformable solid architectures.
- Improved physicochemical and morphological attributes of modified MSNs.
Conclusions:
- Re-engineering stable siliceous frameworks is crucial for overcoming MSN limitations.
- Modified MSNs offer enhanced drug delivery and reduced toxicity.
- Future perspectives focus on advanced MSN designs for biomedical applications.
