Related Experiment Video
Updated: Dec 1, 2025
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
5.7K
Coagulation markers as predictors for clinical events in COPD
Gunnar R Husebø1,2, Esteban C Gabazza3, Corina D'Alessandro Gabazza3
1Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
Respirology (Carlton, Vic.)
|November 9, 2020
Summary
Coagulation activation increases during COPD exacerbations. Specific markers like D-dimer and TAT can predict future COPD events and mortality in patients.
Area of Science:
- Pulmonary Medicine
- Hematology
- Inflammation Research
Background:
- Blood coagulation system activation is common in inflammatory diseases.
- The specific role of coagulation in Chronic Obstructive Pulmonary Disease (COPD) remains underexplored.
Purpose of the Study:
- To investigate the activation of the coagulation system in COPD patients.
- To determine if coagulation markers can predict future COPD exacerbations and mortality.
Main Methods:
- Analysis of 413 COPD patients and 49 controls from the Bergen COPD Cohort Study (BCCS).
- Measurement of plasma coagulation markers (TAT complex, APC-PCI complex, D-dimer) at baseline and during exacerbations.
- Statistical analysis using negative binomial and Cox regression to assess associations with AECOPD and mortality.
Main Results:
- Coagulation markers (TAT, APC-PCI, D-dimer) were significantly elevated during AECOPD compared to stable COPD.
- Higher D-dimer levels in stable COPD predicted increased mortality.
- Elevated TAT levels were associated with an increased risk of future exacerbations and a faster time to the first exacerbation.
Conclusions:
- Coagulation system activation is heightened during COPD exacerbations.
- Coagulation markers show potential as predictive indicators for future COPD exacerbations and patient mortality.
Keywords:
COPDchronic obstructive pulmonary diseasecoagulation markerexacerbationinflammationmortalityMore Related Videos
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
1.6K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
377
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
377
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
139
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
139
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
612
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
612
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.9K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.9K
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
149
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
149