Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

937
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
937
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement and Maintenance of Remission with Upadacitinib in Patients with Moderate-to-Severe Rheumatoid Arthritis in Italy: 1-Year Data from UPHOLD, a Prospective Real-World Observational Study.

Rheumatology and therapy·2026
Same author

Micro- and Macro-Vascular Disease in Systemic Sclerosis and Very Early SSc (VEDOSS): Results from a Monocentric Observational Study.

Biomedicines·2026
Same author

Allergic Diseases in Common Variable Immunodeficiency: A Prospective Cross-Sectional Study on Prevalence and Allergy Biomarkers of Clinical Phenotypes.

Scandinavian journal of immunology·2026
Same author

Efficacy of Dupilumab in Asthma: Focus on Early, Progressive, and Long-Lasting Effects on Small Airways.

Allergy·2025
Same author

Systemic Sclerosis: A Key Model of Endothelial Dysfunction.

Biomedicines·2025
Same author

Hypogammaglobulinemia in patients affected by limited cutaneous systemic sclerosis: Case series and review of the literature.

Journal of scleroderma and related disorders·2025

Related Experiment Video

Updated: Dec 1, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.7K

Putative functional pathogenic autoantibodies in systemic sclerosis.

Devis Benfaremo1, Silvia Svegliati Baroni1, Lucia Manfredi1

  • 1Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.

European Journal of Rheumatology
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) involves complex immune interactions, particularly from B cells releasing profibrotic factors. Novel autoantibodies targeting extracellular matrix and cell surfaces may play a pathogenic role in SSc.

More Related Videos

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

446
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.1K

Related Experiment Videos

Last Updated: Dec 1, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.7K
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

446
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.1K

Area of Science:

  • Immunology
  • Rheumatology
  • Pathogenesis of Systemic Sclerosis

Background:

  • Systemic sclerosis (SSc), or scleroderma, is characterized by vascular damage, fibrosis, and autoantibodies.
  • Immune system dysregulation, involving both innate and adaptive immunity, is central to SSc pathogenesis.
  • B cells are increasingly recognized for their role in SSc, producing autoantibodies and profibrotic cytokines.

Purpose of the Study:

  • To review recently identified autoantibodies in SSc patients.
  • To discuss the potential pathogenic roles of these novel autoantibodies.
  • To focus on autoantibodies targeting extracellular matrix and cell surface antigens.

Main Methods:

  • Review of scientific literature on SSc autoantibodies.
  • Analysis of characterized novel autoantibodies in SSc.
  • Discussion of autoantibody targets and their relation to SSc pathology.

Main Results:

  • Several novel autoantibodies have been identified in SSc patients.
  • These autoantibodies target antigens in the extracellular matrix or on cell surfaces.
  • Some novel autoantibodies exhibit stimulatory or inhibitory activities relevant to SSc lesions.

Conclusions:

  • Novel autoantibodies in SSc may be pathogenic due to their targets and activities.
  • Further characterization of these autoantibodies is crucial for understanding SSc.
  • B cell-derived autoantibodies represent a significant area for SSc research.