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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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Enabling Lyophilized Pneumococcal Conjugate Vaccines Through Formulation Design and Excipient Selection Suitable for

Christopher Mensch1, Ramesh Chintala2, Denise Nawrocki3

  • 1Biologics and Vaccines Analytical, MMD, Merck & Co., Inc., West Point, PA, USA.

Journal of Pharmaceutical Sciences
|November 9, 2020
PubMed
Summary

Researchers developed a novel lyophilized pneumococcal conjugate vaccine (PCV) formulation with 15 serotypes. This innovation offers improved thermostability and broader coverage, addressing gaps in global vaccine access.

Keywords:
AdjuvantsAgglomerationAlumFormulation developmentLyophilizationPneumococcal conjugate vaccineStability

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