In-hospital outcomes of COVID-19 ST-elevation myocardial infarction patients

Area of Science:

• Cardiology
• Infectious Diseases
• Public Health

Background:

• COVID-19 has emerged as a significant comorbidity impacting cardiovascular health.
• ST-elevation myocardial infarction (STEMI) is a critical cardiovascular emergency requiring prompt intervention.

Purpose of the Study:

• To compare clinical characteristics, procedural aspects, and in-hospital outcomes of STEMI patients with and without COVID-19.
• To identify specific risks and prognostic differences associated with concurrent COVID-19 infection in STEMI patients.

Main Methods:

• A nationwide registry analysis of consecutive STEMI patients within specialized care networks.
• Comparison of patient demographics, clinical presentation, procedural interventions, and in-hospital outcomes between COVID-19 positive and negative STEMI cohorts.

Main Results:

• COVID-19 patients presented with more frequent heart failure on arrival (31.9% vs 18.4%).
• Increased rates of mechanical thrombectomy and GP IIb/IIIa inhibitor use were observed in COVID-19 patients.
• COVID-19 patients exhibited substantially higher in-hospital mortality (23.1% vs 5.7%), stent thrombosis (3.3% vs 0.8%), and cardiogenic shock post-PCI (9.9% vs 3.8%).

Conclusions:

• Concurrent COVID-19 infection significantly elevates in-hospital mortality risk in STEMI patients.
• STEMI patients with COVID-19 face increased risks of stent thrombosis and cardiogenic shock following percutaneous coronary intervention (PCI).
• Findings highlight the critical impact of COVID-19 on STEMI prognosis, necessitating tailored management strategies.