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Customizing TMS Applications in Traumatic Brain Injury Using Neuroimaging
Amy A Herrold1, Shan H Siddiqi, Sherri L Livengood
1Edward Hines Jr VA Hospital, Research Service, Hines, Illinois (Drs Herrold, Livengood, and Bender Pape); Dept. of Psychiatry & Behavioral Sciences (Dr Herrold), Dept. of Physical Medicine and Rehabilitation (Drs Livengood, Bender Pape, and Raij), Dept. of Radiology (Mr Higgins), Feinberg School of Medicine, Northwestern University Interdepartmental Neuroscience Program (Dr Raij), and Department of Neurobiology, Weinberg College of Arts and Sciences (Dr Raij), Northwestern University, Chicago, Illinois; Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Boston, Massachusetts (Dr Siddiqi); Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (Dr Siddiqi); Rehabilitation Service, VA Palo Alto Health Care System, Palo Alto, California (Dr Adamson); Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California (Dr Adamson); Department of Anesthesiology, Center for Pain Medicine, UCSD School of Medicine, La Jolla, California (Dr Leung); Center for Pain and Headache Research VA San Diego Healthcare System, San Diego, California (Dr Leung); and Center for Brain Stimulation, Shirley Ryan AbilityLab, Chicago, Illinois (Dr Raij).
Customizing transcranial magnetic stimulation (TMS) for traumatic brain injury (TBI) using neuroimaging is feasible. Further research is needed to confirm if this approach enhances clinical outcomes for TBI patients.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Traumatic brain injury (TBI) is a complex condition with varied anatomical presentations.
- Optimizing treatments like transcranial magnetic stimulation (TMS) for TBI and co-occurring conditions requires personalized approaches.
- Neuroimaging offers potential for customizing TMS interventions.
Purpose of the Study:
- To investigate the feasibility of using multimodal neuroimaging data to customize TMS treatment for individuals with TBI.
- To explore the potential of neuroimaging-guided TMS for understanding brain network changes in TBI.
Main Methods:
- A proof-of-concept study integrating data from 5 analyses/studies.
- Utilized multimodal neuroimaging: structural MRI, functional MRI, diffusion MRI, and MRI-guided TMS navigation.
- Assessed outcomes using symptom scales, neuropsychological tests, and physiological measures.
Main Results:
- It is feasible to customize TMS targets using multimodal neuroimaging data in TBI patients.
- This approach allows for the understanding of brain-based changes within targeted networks.
- Preliminary evidence supports the feasibility of multimodal neuroimaging for TMS customization.
Conclusions:
- Multimodal neuroimaging-based customization of TMS for TBI is feasible.
- Further studies are required to determine if this customized approach improves clinical efficacy.
- Integration of neuroimaging and TMS targeting data with patient outcomes is crucial for future research.
