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Normal Variants in Magnetoencephalography.

Stefan Rampp1,2, Yosuke Kakisaka3, Sumiya Shibata4

  • 1Department of Neurosurgery, University Hospital, Erlangen, Germany.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Normal variants on EEG and MEG can mimic epileptic activity, potentially leading to misdiagnosis and surgical mislocalization. This review clarifies these benign variants in both EEG and magnetoencephalography.

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Area of Science:

  • Neuroscience
  • Clinical Neurophysiology
  • Epileptology

Background:

  • Normal variants in electroencephalography (EEG) can be mistaken for epileptic seizures, leading to diagnostic errors.
  • Misinterpretation is particularly critical in presurgical evaluations, where it can cause incorrect localization and negatively impact surgical outcomes.
  • Limited research exists on the appearance of these variants in magnetoencephalography (MEG) compared to EEG.

Purpose of the Study:

  • To review benign epileptiform variants and their presentation in both EEG and MEG.
  • To highlight MEG-specific normal variants that lack EEG counterparts.
  • To discuss the potential for oscillatory configurations in various frequency bands to be misinterpreted as epileptic activity.

Main Methods:

  • Review of existing literature on benign epileptiform variants.
  • Presentation of comparative examples of variants in EEG and MEG recordings.
  • Discussion of oscillatory patterns and their potential for misinterpretation.

Main Results:

  • Normal variants can closely resemble epileptic discharges in both EEG and MEG.
  • Some variants are unique to MEG and do not have EEG equivalents.
  • Oscillatory configurations across different frequency bands may be erroneously identified as epileptic activity.

Conclusions:

  • Accurate differentiation between normal variants and true epileptic activity is crucial for correct diagnosis and treatment planning.
  • Understanding EEG and MEG variants is essential for neurophysiologists and clinicians, especially in presurgical epilepsy evaluations.
  • Further research into MEG-specific variants and oscillatory phenomena is warranted to improve diagnostic accuracy.