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Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
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Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform.

Shreedevi Arun Kumar1, Jihui Lee1, Corey J Bishop2

  • 1Department of Biomedical Engineering, Texas A&M University.

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A new vaccine delivery system, polybubbles, offers delayed release and can be activated by lasers. This injectable platform improves vaccine cargo protection and release profiles for better global immunization.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Effective vaccine delivery is essential for global immunization, but current methods face challenges with cargo protection and controlled release.
  • Organic solvents used in some delivery systems can degrade vaccine cargo and limit release options.

Purpose of the Study:

  • To introduce a novel, injectable vaccine delivery platform called polybubbles.
  • To demonstrate the platform's ability to protect cargo from organic solvents and provide delayed burst release.
  • To explore on-demand cargo release using near-infrared laser activation.

Main Methods:

  • Polyester-based polybubbles were fabricated in a carboxymethylcellulose aqueous solution.
  • Protocols were developed for maintaining polybubble shape and optimizing cargo loading.
  • Neutron activation analysis was used to quantify residual chlorinated solvents.
  • Release studies with small molecules and gold nanorods were performed.

Main Results:

  • The polybubble platform successfully protected encapsulated cargo from organic solvents.
  • Delayed burst release of small molecule cargo was confirmed.
  • Incorporation of gold nanorods enabled near-infrared laser-triggered release.

Conclusions:

  • Polybubbles represent a promising injectable vaccine delivery system with tunable release kinetics.
  • The platform offers enhanced cargo protection and potential for on-demand, triggered delivery.
  • This technology could significantly improve vaccine efficacy and global immunization coverage.