Zosteriform Cutaneous Metastases with Primary Endometrial Carcinoma

Area of Science:

• Oncology
• Dermatology
• Gynecologic Oncology

Background:

• Endometrial adenocarcinoma commonly metastasizes to pelvic and para-aortic lymph nodes, peritoneum, vagina, and lungs.
• Cutaneous metastases from endometrial cancer are infrequent and often indicate a poor prognosis.
• The zosteriform (shingles-like) pattern of metastasis is a rare manifestation.

Observation:

• A 60-year-old female patient with a diagnosis of endometrial carcinoma presented with a distinctive zosteriform rash.
• The skin lesions were identified as cutaneous metastases originating from the primary endometrial tumor.
• This presentation is unusual given the typical metastatic sites for this cancer.

Findings:

• The case confirms that endometrial adenocarcinoma can present with zosteriform cutaneous metastases, a rare but possible clinical scenario.
• Diagnostic confirmation involved histopathological examination of the skin lesions, revealing metastatic adenocarcinoma cells.
• The zosteriform spread suggests a specific neurotropic or lymphatic spread pattern.

Implications:

• Recognizing rare metastatic patterns like zosteriform cutaneous involvement is crucial for timely diagnosis and management of endometrial cancer.
• This case expands the understanding of the potential dissemination routes of endometrial adenocarcinoma.
• Early identification of such unusual metastases may prompt a re-evaluation of treatment strategies and prognostic assessments.