Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.5K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.5K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.4K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.6K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.6K
Lineage Commitment01:21

Lineage Commitment

3.8K
Commitment is the  process whereby stem cells:
3.8K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.1K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.7K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting oncogene-induced senescence in ETV6::RUNX1 pre-leukemic cells.

Cell death discovery·2026
Same author

Deletion of 9p drives B-ALL through heterozygous inactivation of Pax5 and Cd72 in preleukemic cells.

JCI insight·2026
Same author

PD-1 Expression Promotes Immune Evasion in B-ALL.

Hematology reports·2025
Same author

Childhood leukemia prevention within reach.

Blood·2024
Same author

Childhood B cell leukemia: Intercepting the paths to progression.

BioEssays : news and reviews in molecular, cellular and developmental biology·2024
Same author

Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.

Cancer discovery·2024

Related Experiment Video

Updated: Dec 1, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.4K

Leukemia Stem Cells: Concept and Implications.

Isidro Sánchez-García1, César Cobaleda2

  • 1Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca and Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs), including leukemia stem cells (LSCs), are now recognized but their full impact on cancer research and treatment is still emerging. Understanding LSC properties is crucial for advancing leukemia research and patient care.

Keywords:
Animal modelsCancer stem cellsEpigenetic reprogrammingLeukemiaLeukemic stem cells

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.5K
Author Spotlight: Innovative Laser Techniques for Hoechst Staining to Analyze Side Population Cells
06:31

Author Spotlight: Innovative Laser Techniques for Hoechst Staining to Analyze Side Population Cells

Published on: August 23, 2024

1.9K

Related Experiment Videos

Last Updated: Dec 1, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.4K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.5K
Author Spotlight: Innovative Laser Techniques for Hoechst Staining to Analyze Side Population Cells
06:31

Author Spotlight: Innovative Laser Techniques for Hoechst Staining to Analyze Side Population Cells

Published on: August 23, 2024

1.9K

Area of Science:

  • Hematology
  • Oncology
  • Cancer Biology

Background:

  • The existence of cancer stem cells (CSCs) was once debated but is now established in most tumor types.
  • The full clinical and research implications of CSCs are yet to be realized, necessitating a paradigm shift in cancer understanding.
  • Leukemia stem cells (LSCs) represent a critical subset of CSCs with significant implications for leukemia.

Purpose of the Study:

  • To provide a primer on leukemia stem cells (LSCs).
  • To outline the key properties of LSCs and their identification methods.
  • To discuss the implications of LSC existence for leukemia research and treatment strategies.

Main Methods:

  • Review of existing literature on cancer stem cells and leukemia stem cells.
  • Synthesis of information regarding LSC properties and identification.
  • Discussion of the translational and clinical relevance of LSC research.

Main Results:

  • CSCs, including LSCs, are demonstrably present in various cancers.
  • Specific properties of LSCs have been identified, leading to their characterization.
  • The understanding of LSCs necessitates a re-evaluation of cancer biology and therapeutic approaches.

Conclusions:

  • The recognition of LSCs represents a fundamental change in understanding leukemia.
  • Further assimilation of LSC implications is vital for advancing leukemia research.
  • Applying LSC insights to treatment strategies holds promise for improving outcomes in leukemia patients.