Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.4K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.5K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.6K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.6K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

665
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
665

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting oncogene-induced senescence in ETV6::RUNX1 pre-leukemic cells.

Cell death discovery·2026
Same author

Deletion of 9p drives B-ALL through heterozygous inactivation of Pax5 and Cd72 in preleukemic cells.

JCI insight·2026
Same author

PD-1 Expression Promotes Immune Evasion in B-ALL.

Hematology reports·2025
Same author

Childhood leukemia prevention within reach.

Blood·2024
Same author

Childhood B cell leukemia: Intercepting the paths to progression.

BioEssays : news and reviews in molecular, cellular and developmental biology·2024
Same author

Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.

Cancer discovery·2024

Related Experiment Video

Updated: Dec 1, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.4K

Leukemia Stem Cell Drug Discovery.

César Cobaleda1, Isidro Sánchez-García2

  • 1Immune System Development and Function Unit, Centro de Biologia Molecular "Severo Ochoa" (CSIC/UAM), Madrid, Spain. cesar.cobaleda@csic.es.

Methods in Molecular Biology (Clifton, N.J.)
|November 9, 2020
PubMed
Summary
This summary is machine-generated.

Developing better cancer models is crucial for effective cancer drug discovery. Improved animal models, based on cancer stem cell theory, can enhance drug development success and reduce patient trials.

Keywords:
Animal modelsCancer stem cellsEpigenetic reprogrammingLeukemiaLeukemic stem cells

More Related Videos

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia
05:24

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Published on: February 21, 2021

4.5K
Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.6K

Related Experiment Videos

Last Updated: Dec 1, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.4K
Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia
05:24

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Published on: February 21, 2021

4.5K
Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.6K

Area of Science:

  • Oncology
  • Translational Medicine
  • Drug Development

Background:

  • Cancer patient survival rates have stagnated despite advances in molecular understanding.
  • The number of effective cancer drugs is declining, with many lacking sufficient evidence of benefit.

Purpose of the Study:

  • To discuss the redesign of cancer therapy development.
  • To highlight the need for improved animal models in preclinical drug development.
  • To propose the use of cancer stem cell theory in creating better models.

Main Methods:

  • Discussion of current limitations in cancer drug development.
  • Analysis of the discordance between preclinical and clinical trial results.
  • Proposal for the generation of novel animal models.

Main Results:

  • Inappropriate animal models contribute significantly to drug development failures.
  • Improved models can recapitulate human cancer aspects more accurately.
  • Better models are expected to increase the success rate of drug candidates.

Conclusions:

  • Redesigning cancer therapy development requires better preclinical models.
  • Cancer stem cell-based models offer a promising approach for improved drug testing.
  • Enhanced models can reduce the number of ineffective agents entering clinical trials and spare patients from futile treatments.