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Updated: Dec 1, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles
Jennifer Huxham1,2, Sébastien Tabariès1,2, Peter M Siegel1,2,3,4,5
1Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada.
Abstract:
Adherens (AJ) and tight junctions (TJ) maintain cell-cell adhesions and cellular polarity in normal tissues. Afadin, a multi-domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal-modulating roles. Afadin is a complex modulator of cellular processes implicated in cancer progression, including signal transduction, migration, invasion, and apoptosis. In keeping with the complexities associated with the roles of adherens and tight junctions in cancer, afadin exhibits both tumor suppressive and pro-metastatic functions. In this review, we will explore the dichotomous roles that afadin plays during cancer progression.
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