Balanced spin-lock preparation for B₁ -insensitive and B₀ -insensitive quantification of the rotating frame...

Accurate and artifact-free T_1ρ quantification is still a major challenge due to a susceptibility of the spin-locking module to B₀ and/or B₁ field inhomogeneities. In this study, we present a novel spin-lock preparation module (B-SL) that enables an almost full compensation of both types of inhomogeneities.

The new B-SL module contains a second 180° refocusing pulse to compensate each pulse in the preparation block by a corresponding pulse with opposite phase. For evaluation and validation of B-SL, extensive simulations as well as phantom measurements were performed. Furthermore, the new module was compared to three common established compensation methods.

Both simulations and measurements demonstrate a much lower susceptibility to artifacts for the B-SL module, therefore providing an improved accuracy in T_1ρ quantification. In the presence of field inhomogeneities, measurements revealed an increased banding compensation by 79% compared with the frequently used composite module. The goodness of the mono-exponential T_1ρ fitting procedure was improved by 58%.

The B-SL preparation enables the generation of accurate relaxation maps with significantly reduced artifacts, even in the case of large field imperfections. Therefore, the B-SL module is suggested to be highly beneficial for in vivo T_1ρ quantification.