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Hydroxyl Group-Directed Solvation of Excited-State Intramolecular Proton Transfer Probes in Water: A Demonstration
Sinjan Das1, Shounak Mukherjee2, Suman Chakrabarty2
1Department of Chemistry, Jadavpur University, Kolkata 700 032, India.
Abstract:
Formation of a probe-solvent network resulting in unusually high fluorescence anisotropy (FA) of an excited-state intramolecular proton transfer (ESIPT) probe, 3-hydroxyflavone (3HF), in water prompted us to explore the solvation patterns on its 7-hydroxy (7HF) and 6-hydroxy (6HF) positional analogues. In the present study, it was observed that 7HF exhibits a lower FA than 3HF does in water, implying that the volume of the 7HF-water cluster is less than that of the 3HF-water cluster. Experimental and computational results led us to propose that 7HF forms its water cluster at the molecular periphery in contrast to the projected-out structure in case of the 3HF-water cluster. Density functional theory (DFT)-based quantum chemical calculations provide an approach for the differential solvation patterns of 3HF and 7HF. 6HF, a non-ESIPT probe, exhibits very low FA in water compared with both 3HF and 7HF. This study demonstrates that proper positioning of the hydroxyl group and its participation in the extended π-conjugation within the molecule dictate the formation of the solvated cluster endorsing directed solvation.
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